Higuchi connors phase solubility techniques.

Phase solubility measurements of SBE 7-β-CD and valsartan were performed using the Higuchi-Connors technique . In separate conical flasks holding 10 ml of distilled water having increasing concentrations of SBE 7 -β-CD starting from 0.5 to 5 mM, an excess of valsartan was added.The phase solubility diagrams for curcumin/cyclodextrin polymer inclusion complex is shown in Figure 5, which displayed an AL-type according to Higuchi and Connors . According to Higuchi and Connors’ theory, the 1:1 stoichiometry of the inclusion complex was achieved from the initial ascending part of the curve, a nearly …Phase solubility techniques @inproceedings{Higuchi1965PhaseST, title={Phase solubility techniques}, author={Takeru. Higuchi and Andrew L. Connors}, year={1965}, url={https://api.semanticscholar.org/CorpusID:100897505} } T. Higuchi, A. Connors; Published 1965; Chemistry The results showed an increase in the apparent solubility of ibuprofen in the presence of maltodextrins that depended on their ionization state. The freeze-drying method was used to prepare solid complexes, while physical mixtures were obtained by simple blending.

Feb 28, 2023 · According to the classification of the phase solubility diagram of Higuchi and Connors (Eq. 1), the HO-AAVPA solubility profiles correspond to the type A L phase diagrams, which support the ... The phase solubility study was carried by the Higuchi and. Connors ... 2011 Jul 1;3(3):205-10. 27. Higuchi. T., Connors. K. phase solubility techniques.advanced.

Jun 15, 2019 · Solubility phase diagrams were created to evaluate the molar ratios of GAZ/βCD and GAZ/γCD inclusion complexes and their stability in aqueous solution (Fig. 2).The solubility of GAZ increased linearly with the added concentrations of βCD and γCD and produced an A L solubility phase diagram according to the classification by Higuchi, Connors et al. [12] A-type diagrams are formed when the ...

T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following …The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors . The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. 1. The apparent solubility of DMA increased ...According to the Higuchi and Connors classification [6], the phase solubility diagram for the repaglinide – HP- β-CD inclusion complex is A type, which indicates the formation of a soluble complex.To determine binding constants by Higuchi and Connors method, the acids solubility was determined by CZE after their agitation in the solutions of HP-γ-CD (with 0.6 molar substitution) at 25 °C for 3 days. The dependences of acids solubility on HP-γ-CD concentration deviated from straight line in the range of high concentration (A N mode ...The complexation of diosmin with βCD and HPβCD both indicated an AL type of phase-solubility diagrams, and the apparent stability constants (Kc) was found to be 222.13 and 200.08 M(-1 ...

Article Original Paper Published: 08 August 2022 Mangiferin/ β -cyclodextrin complex: determination of the Inclusion constant in aqueous solution by Higuchi-Connors method and molecular absorption and photoluminescence UV spectroscopies at pH 3.4 Lucero Hernández-García, Alberto Rojas-Hernández & Annia Galano

according to Higuchi and Connors (10). Briefly, an excess amount of paracetamol ... Phase solubility techniques. In: Reilley CN. (ed.) Advances in Analytical ...

(3) (Higuchi and Connors, 1965). As mentioned pre- viously poorly soluble ... Phase-solubility techniques. Adv. Anal. Chem. Instrum. 4, 117–212. Johnson ...According to the classification of the phase solubility diagram of Higuchi and Connors (Eq. 1), the HO-AAVPA solubility profiles correspond to the type A L phase diagrams, which support the ...Higuchi T, Connors K. Phase-solubility techniques. Adv Anal Chem Instrum. 1965;7:117–212. Google Scholar Jouyban A. Handbook of solubility data for pharmaceuticals. Boca Raton: CRC Press; 2009. United States Pharmacopeial Convention. USP 38–NF 33, General notices and requirements.Phase solubility studies. Solubility measurements were performed in triplicate using the method reported by Higuchi and Connors (Higuchi et al., 1965). An excess amount of ALLO was added to the aqueous solutions of each carrier containing increasing concentrations of the individual carrier (i.e., 0, 1, 5, and 10 % w/v).The solubility of hydrocortisone (HC) was measured in water containing varying concentrations of γCD. The resulting B S-type phase-solubility diagram was described within the theoretical framework laid out by Higuchi and Connors. The initial linear increase in the solubility at low concentrations of γCD was caused by the formation of a water ...The purpose of the present work is to improve the antimalarial activity of arteether through enhancing its solubility subsequently bioavailability by incorporating the drug into the cyclodextrins cavity. ... A 1:1 stoichiometry was proposed by the phase solubility studies both in presence and absence of PVP. ... T. Higuchi, K. A. Connors ...Fig. 3 displays the effects CDs can have on drug solubility and the classification of the profiles (Higuchi and Connors, 1965). A-type phase solubility profiles are acquired when the solubility of the drug increases with increasing CD concentration through formation of water-soluble drug/CD complexes.

Types of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration.method described by Higuchi & Connors et al [18]. Excess NSF (100 mg) was added to a 50 m L . ... [18] Higuchi T and Connors K A 1965 Phase solubility techniques Advances in Analyt ical Chemistry .Citation University of Kansas. Kenneth Spencer Research Library Personal papers of Takeru Higuchi (PP 359) Articles arranged alphabetically by title: Higuchi A-Z; Higuchi et. al. A-Z Higuchi and Connors, "Phase-Solubility Techniques,", 1964 Dates Creation: 1964 Collapse All Get at Spencer Box: 11, Folder: 35 (Mixed Materials) Repository DetailsSolubility studies used deionized water, and 1 H NMR spectra were of solutions in deuterium oxide (D 2 O, deuterium content 99.8%) from Fluka (Barcelona, Spain). 2.2. Phase solubility studiesSolubility measurements were carried out according to the method of Higuchi and Connors (1965). Excess amounts of clofibrate were added to a series of ...also calculated whe re possible accordin g to Higuchi-Connors. 8 The methodolog y employed for . ... Connors KA. Phase Solubility Techniques. Advances in Analytical Chemistry and Instrumentation ...The phase solubility curve was a typical AL-type curve, as described in solubility diagrams by Higuchi and Connors. A regression coefficient (R 2) exceeding 0.99 and slope value (0.0732) of less than 1 revealed the formation of the KME/HP-β-CD system with a 1:1 stoichiometry. The Ks of KME/HP-β-CD were calculated based on the …Levemopamil was solubilized by varying the concentration of hydroxypropyl-β-cyclodextrin (HPβCD) and by the alteration of pH.The drug molecule has two sites for possible complexation with HPβCD, creating the possibility of either 1:1 or 1:2 complexation.The solubility as a function of HPβCD concentration of the charged and …

Phase Solubility Studies. Phase solubility studies were carried out at room temperature (21 ± 1°C) following the method of Higuchi and Connors . Excess amounts of OME were weighed in glass flasks to which 10 ml of boric/borate buffer pH = 10 were added. These flasks contained increasing amounts of βCD (0–1.5%, w/v) or MβCD (0–5%, w/v).

All the formulations were evaluated at pre and post compression level. Acid solubility profile showed higher solubility in HCl buffer pH2 (296.89±3.49 μg/mL). Mixture of propylene glycol and ...Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117–212. Google ScholarHiguchi and Connors, "Phase-Solubility Techniques,", 1964, Box: 11, Folder: 35. Personal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer Research Library. Copy to clipboard Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, …31 Ağu 2017 ... The phase solubility studies were carried out to study the effect of cyclodextrins according to the method described by Higuchi and Connors. The ...3.8. Solubility Studies. The phase-solubility profiles of the three polymorphic forms of benzocaine were determined according to the method of Higuchi and Connors , and were performed by using a Thermo Scientific™ MaxQ™ 4450 Benchtop Orbital Shaker (Thermo Scientific, Waltham, MA, USA). To 25.0 mL flasks, containing 10.0 mL methanol …Higuchi T, Connors K (1965) Phase solubility techniques. In: Reilly CN (ed) Advances in analytical chemistry instrumentation. Interscience, New York, NY, pp 117–212. Google Scholar Jozefaciuk G, Muranyi A, Fenyvesi E (2001) Effect of cyclodextrins on surface and pore properties of soil clay minerals. Environ. Sci.

All the phase-solubility diagrams were of type A except the diagrams of hydrocortisone in γCD and 80/20 γCD/HPγCD solutions were of B S-type according to the Higuchi-Connor classification system. 22 The slopes of the initial linear sections of the diagrams were determined and both the apparent stability constants (K 1:1) and the …

The shake-fl ask method proposed by Higuchi and Connors is the most reliable and widely used solubility measurement method. ... K. A. Connors, Phase-solubility techniques, Adv. Anal. Chem. Instr ...

The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone ...Mar 10, 2023 · Phase-solubility profiles and classification of drug/CD complexes according to Higuchi and Connors . Figure 2. In general, one drug molecule (D) forms a complex with one CD molecule in pure water, and, if the complex is water-soluble, an A L -type phase-solubility diagram is observed ( Table 1 ). The phase solubility diagrams for curcumin/cyclodextrin polymer inclusion complex is shown in Figure 5, which displayed an AL-type according to Higuchi and Connors . According to Higuchi and Connors’ theory, the 1:1 stoichiometry of the inclusion complex was achieved from the initial ascending part of the curve, a nearly …If inclusion complexation were the only contribution to drug solubility, it would increase linearly with CD concentration (as per the Higuchi–Connors model); this is because inclusion complexation is a 1 : 1 stoichiometric process. However, solubility curves often deviate from this linearity, whose mechanism is yet to be understood.Abstract. The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance ...24 Oca 2006 ... reported by Higuchi and Connors.17 Excess drug (25 mg) was added to 15 mL of ... Phase-solubility techniques. In: Reilly CN, ed. Advances in ...Phase Solubility Study. Phase solubility study was carried out according to the Higuchi and Connors method . For phase solubility study of a binary system, an excess amount of PLDN was added to aqueous solutions containing increasing concentrations of β-CD (3–15 mM). The solutions were kept on rotary shaker for 48 h at 25 °C.24 Tem 2018 ... This phase-solubility technique was first developed by Higuchi and Connors. ... complex formation solubility, spectral and kinetic techniques. J ...Types of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration.T. Higuchi, K. A. Connors, "Phase Solubility Techniques," Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo StudiesThe effect of L-arginine was investigated on complexation efficiency of β-cyclodextrin towards Epalrestat in an aqueous media through phase solubility according to Higuchi and Connors. Phase ...

Higuchi T, Connors K. Phase-solubility techniques. Adv Anal Chem Instrum. 1965;7:117–212. Google Scholar Jouyban A. Handbook of solubility data for pharmaceuticals. Boca Raton: CRC Press; 2009. United States Pharmacopeial Convention. USP 38–NF 33, General notices and requirements.Aug 8, 2022 · Stoichiometry and constant formation of the inclusion complex 1H 4 MGF:1βCD by Higuchi–Connors method. The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ([H 4 MGF] = f([βCD])) of saturated solutions in mangiferin must show a linear trend and then equation relates the slope (α) and intercept ... Solubility method (phase solubility analysis) Solubility studies were carried out according to the method reported by Higuchi and Connors (1965) . Excess amounts of DAN were added to aqueous solutions (pH 6.2 ± 0.1) containing increasing concentrations of BCD (2.0 × 10 −3 to 14.0 × 10 −2 M) and the samples were shaken on a rotary shaker ...Instagram:https://instagram. big breasted indianjd and msw dual degree programspirates treasure chapter 8dr theodore wilson Dec 15, 2014 · Phase solubility studies. The phase solubility studies were performed using Higuchi and Connors method (Higuchi & Connors, 1965). Briefly, different concentrations of β-CD (0, 2, 6, 8, 10 and 20 mM) were prepared in deionised water in glass capped vials. To each vial 1 mg CUR was added. score of the ku basketball game todaypay deposit The solubilities of voriconazole, ketoconazole, and clotrimazole with and without hydroxybutenyl-β-cyclodextrin (HBenBCD) in aqueous media were examined. The solubility of these antifungal drugs was significantly improved by complexation with HBenBCD. Both the pH and the type of buffer used to adjust the medium pH had a very significant effect on drug solubilities and the apparent binding ...Feb 28, 2023 · According to the classification of the phase solubility diagram of Higuchi and Connors (Eq. 1), the HO-AAVPA solubility profiles correspond to the type A L phase diagrams, which support the ... phd human behavior online Phase solubility study. Classification of inclusion complex formation and stability of the inclusion compounds were evaluated by phase solubility study (Higuchi & Connors, 1965). An excess of black pepper oil was added to 10 mL aqueous solutions of HPβCD ranging in concentration from 0 to 10 mmol/L and incubated at 25 and 35 °C for …In this regard, the well-known solubility diagram design (T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212) should be done in order to obtain information about the drug solubility in presence of increasing CD concentrations.