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Adrafinil, 2- ( (diphenylmethyl)sulfinyl)-N-hydroxyacetamide, is a drug designed for the treatment of narcolepsy by promoting an awakened state, and to treat alertness and neurological symptoms in the elderly. It is primarily metabolized in vivo to an active form, i.e. modafinil, 2- ( (diphenylmethyl)sulfinyl)acetamide.

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Adrafinil is very structurally similar to its close chemical cousin and bioactive metabolite, modafinil. The only structural difference is the that terminal amide hydroxyl group of adrafinil ((diphenylmethyl)sulfinyl-2 acetohydroxamic acid) is lacking in modafinil (diphenylmethyl)sulfinyl-2 acetamide). is a eugeroic that was formerly used in ...

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